Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva Papilloma skin lesions.
Department of Ophthalmology, Grigore T. E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of papilloma lesions conjunctiva of the left eye. The method used for the detection of HPV was real time polymerase chain reaction.
The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, papilloma lesions cell carcinoma Human papilloma lesions HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.
The papilloma lesions between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation papilloma lesions that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells. Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for papilloma lesions 1-year and a half.
He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.
The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses.
All other ophthalmological findings were normal.
Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the head and neck showed papilloma lesions signs of tumor invasion of the orbit or the lymph nodes. The limbic lesion was removed surgically with 2 mm margin of normal papilloma lesions and diathermy of the adjacent sclera was done.
At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position papilloma lesions interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one papilloma lesions HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.
Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without papilloma lesions [Figs.
Studies in recent years have shown that this interaction is more complex, involving multiple cellular and molecular mechanisms. Studiile din ultimii ani au demonstrat că această interacţiune este mai complexă, fiind implicate multiple mecanisme celulare şi moleculare. Infecţia cu virusul imunodeficienţei umane Human Immunodeficiency Virus, HIV este de asemenea o problemă de sănătate globală, Centrul pentru Controlul şi Papilloma lesions Bolilor Centers for Disease Control and Prevention, CDC raportând în existenţa a aproximativ 36,9 milioane de oameni trăind cu această infecţie, dintre care doar 21,7 milioane se aflau sub tratament.