Email Women who carry a faulty copy of a gene called RAD51D have an almost one in 11 chance of developing ovarian cancerscientists said on Sunday in a finding they called the most significant ovarian cancer gene discovery for more than 10 years.
Tests to identify those at highest risk are expected to be available within a few years, according to Cancer Research UK, and may lead some women to decide to have their ovaries removed in order to beat the disease. The finding should also speed the search for new drugs.
The Development of Genetic Testing in Ovarian Cancer
Data released in May showed that one of these, AstraZeneca's olaparib, was able to slow the progression of ovarian cancer in a mid-stage clinical trial. For the latest study, researchers from Britain's Ovarian cancer gene of Cancer Research compared the DNA of women from families ovarian cancer gene ovarian and breast cancer to DNA from a control group of more than 10, people from the general population.
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They found eight faults in the RAD51D gene in women ovarian cancer gene cancer, compared with only one in the control group. Ovarian cancer can remain hidden for a long time and thus is often not discovered until it is advanced.
An estimatedwomen worldwide are diagnosed with ovarian cancer gene cancer each year. Most are not diagnosed before the cancer has spread, and up to 70 percent of them die within five years.
Totul despre tiroida 1 Apply Totul despre tiroida filter Predispozitia genetica in cancerul de san si cancerul ovarian Toate femeile sunt expuse riscului de a dezvolta cancer de san sau cancer ovarian de-a lungul vietii, insa, ovarian cancer gene femei au un risc suplimentar, adesea din cauza factorilor genetici, pe care nu ii pot controla. Cancerul de san este mai putin frecvent la femeile mai tinere, dar femeile tinere au mai multe sanse sa aiba cancer de san ereditar, cauzat de o anomalie genetica mostenita. Ereditatea si mutatiile genetice In mod normal, fiecare persoana are 2 copii ale fiecarei gene: 1 copie este mostenita de la mama si o copie este mostenita de la tata. Cancerele ereditare urmeaza un model transmitere autozomal dominant. Acest lucru inseamna ca o mutatie trebuie sa ovarian cancer gene intr-o singura copie a genei pentru ca persoana sa aiba un risc crescut de a avea boala respectiva.
Because of this, Rahman said, women with the faulty gene may decide their best option is to have their ovaries removed after they have children -- particularly if they have already seen other family members die of the disease. Initial tests in the laboratory found that cells with faulty RAD51D ovarian cancer gene highly sensitive to this class of drugs.